PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells

PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells

Transmembrane prostate androgen-induced protein (TMEPAI), also known as PMEPA1, is highly expressed in many types of cancer and promotes oncogenic abilities. However, the mechanisms whereby TMEPAI facilitates tumorigenesis are not fully understood. We previously established TMEPAI-knockout (KO) cell...

Full description

Bibliographic Details
Main Authors: Md. Anwarul Haque, Mohammed Abdelaziz, Meidi Utami Puteri, Thanh Thao Vo Nguyen, Kosei Kudo, Yukihide Watanabe, Mitsuyasu Kato
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
TMEPAI
TNBC
AKT signaling
PHLPP1
ubiquitination
Online Access:https://www.mdpi.com/2072-6694/13/19/4934

Internet

https://www.mdpi.com/2072-6694/13/19/4934

Similar Items