Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2). As the IL-22R1/IL-10R2 heterodimer is preferentially expressed on border tissue betw...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2021-04-01
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| Series: | Exploration of Immunology |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/ei/Article/10035 |
| _version_ | 1828951398928089088 |
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| author | Masutaka Furue Mihoko Furue |
| author_facet | Masutaka Furue Mihoko Furue |
| author_sort | Masutaka Furue |
| collection | DOAJ |
| description | Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2). As the IL-22R1/IL-10R2 heterodimer is preferentially expressed on border tissue between the host and the environment, IL-22 is believed to be involved in border defense. Epidermal keratinocytes are the first-line skin barrier and express IL-22R1/IL-10R2. IL-22 increases keratinocyte proliferation but inhibits differentiation. Aryl hydrocarbon receptor (AHR) is a chemical sensor and an essential transcription factor for IL-22 production. In addition, AHR also upregulates the production of barrier-related proteins such as filaggrin in keratinocytes, suggesting a pivotal role for the AHR-IL-22 axis in regulating the physiological skin barrier. Although IL-22 signatures are elevated in atopic dermatitis and psoriasis, their pathogenic and/or protective implications are not fully understood. |
| first_indexed | 2024-12-14T06:37:02Z |
| format | Article |
| id | doaj.art-ca334c05404a437f849d4dd89af3cb9a |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-12-14T06:37:02Z |
| publishDate | 2021-04-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-ca334c05404a437f849d4dd89af3cb9a2022-12-21T23:13:20ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552021-04-0111374710.37349/ei.2021.00005Interleukin-22 and keratinocytes; pathogenic implications in skin inflammationMasutaka Furue0https://orcid.org/0000-0002-2967-1073Mihoko Furue1Emeritus Professor, Department of Dermatology, Kyushu University, Higashiku, Fukuoka, 812-8582, JapanIndependent Scholar, Sawaraku, Fukuoka, 814-0006, JapanInterleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2). As the IL-22R1/IL-10R2 heterodimer is preferentially expressed on border tissue between the host and the environment, IL-22 is believed to be involved in border defense. Epidermal keratinocytes are the first-line skin barrier and express IL-22R1/IL-10R2. IL-22 increases keratinocyte proliferation but inhibits differentiation. Aryl hydrocarbon receptor (AHR) is a chemical sensor and an essential transcription factor for IL-22 production. In addition, AHR also upregulates the production of barrier-related proteins such as filaggrin in keratinocytes, suggesting a pivotal role for the AHR-IL-22 axis in regulating the physiological skin barrier. Although IL-22 signatures are elevated in atopic dermatitis and psoriasis, their pathogenic and/or protective implications are not fully understood.https://www.explorationpub.com/Journals/ei/Article/10035il-22il-22 receptoraryl hydrocarbon receptorskin barrierkeratinocyteatopic dermatitispsoriasis |
| spellingShingle | Masutaka Furue Mihoko Furue Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation Exploration of Immunology il-22 il-22 receptor aryl hydrocarbon receptor skin barrier keratinocyte atopic dermatitis psoriasis |
| title | Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation |
| title_full | Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation |
| title_fullStr | Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation |
| title_full_unstemmed | Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation |
| title_short | Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation |
| title_sort | interleukin 22 and keratinocytes pathogenic implications in skin inflammation |
| topic | il-22 il-22 receptor aryl hydrocarbon receptor skin barrier keratinocyte atopic dermatitis psoriasis |
| url | https://www.explorationpub.com/Journals/ei/Article/10035 |
| work_keys_str_mv | AT masutakafurue interleukin22andkeratinocytespathogenicimplicationsinskininflammation AT mihokofurue interleukin22andkeratinocytespathogenicimplicationsinskininflammation |