Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

Abstract Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes from the National Institute on Aging Late‐Onset Alzheimer's Disease Family‐Based Study and a study of famil...

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Bibliographic Details
Main Authors: Min Qiao, Annie J. Lee, Dolly Reyes‐Dumeyer, Giuseppe Tosto, Kelley Faber, Alison Goate, Alan Renton, Michael Chao, Brad Boeve, Carlos Cruchaga, Margaret Pericak‐Vance, Jonathan L. Haines, Roger Rosenberg, Debby Tsuang, Robert A. Sweet, David A. Bennett, Robert S. Wilson, Tatiana Foroud, Richard Mayeux, Badri N. Vardarajan
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51757

Internet

https://doi.org/10.1002/acn3.51757

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