Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation
There are a pressing and unmet need for effective therapies for freezing of gait (FOG) and other neurological gait disorders. Deep brain stimulation (DBS) of a midbrain target known as the pedunculopontine nucleus (PPN) was proposed as a potential treatment based on its postulated involvement in loc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnsys.2020.00064/full |
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| author | Stephano J. Chang Stephano J. Chang Stephano J. Chang Iahn Cajigas Iahn Cajigas Ioan Opris James D. Guest James D. Guest James D. Guest Brian R. Noga Brian R. Noga Brian R. Noga |
| author_facet | Stephano J. Chang Stephano J. Chang Stephano J. Chang Iahn Cajigas Iahn Cajigas Ioan Opris James D. Guest James D. Guest James D. Guest Brian R. Noga Brian R. Noga Brian R. Noga |
| author_sort | Stephano J. Chang |
| collection | DOAJ |
| description | There are a pressing and unmet need for effective therapies for freezing of gait (FOG) and other neurological gait disorders. Deep brain stimulation (DBS) of a midbrain target known as the pedunculopontine nucleus (PPN) was proposed as a potential treatment based on its postulated involvement in locomotor control as part of the mesencephalic locomotor region (MLR). However, DBS trials fell short of expectations, leading many clinicians to abandon this strategy. Here, we discuss the potential reasons for this failure and review recent clinical data along with preclinical optogenetics evidence to argue that another nearby nucleus, the cuneiform nucleus (CnF), may be a superior target. |
| first_indexed | 2024-04-12T08:12:51Z |
| format | Article |
| id | doaj.art-ca346738721644b7bbff3c5d7cf8c8ce |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-04-12T08:12:51Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-ca346738721644b7bbff3c5d7cf8c8ce2022-12-22T03:40:55ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372020-08-011410.3389/fnsys.2020.00064573749Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus StimulationStephano J. Chang0Stephano J. Chang1Stephano J. Chang2Iahn Cajigas3Iahn Cajigas4Ioan Opris5James D. Guest6James D. Guest7James D. Guest8Brian R. Noga9Brian R. Noga10Brian R. Noga11Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, FL, United StatesThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United StatesDivision of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC, CanadaThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United StatesThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United StatesNeuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, FL, United StatesThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United StatesNeuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, FL, United StatesThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United StatesThere are a pressing and unmet need for effective therapies for freezing of gait (FOG) and other neurological gait disorders. Deep brain stimulation (DBS) of a midbrain target known as the pedunculopontine nucleus (PPN) was proposed as a potential treatment based on its postulated involvement in locomotor control as part of the mesencephalic locomotor region (MLR). However, DBS trials fell short of expectations, leading many clinicians to abandon this strategy. Here, we discuss the potential reasons for this failure and review recent clinical data along with preclinical optogenetics evidence to argue that another nearby nucleus, the cuneiform nucleus (CnF), may be a superior target.https://www.frontiersin.org/article/10.3389/fnsys.2020.00064/fullmesencephalic locomotor regiondeep brain stimulationgait dysfunctioncuneiform nucleuspedunculopontine nucleus |
| spellingShingle | Stephano J. Chang Stephano J. Chang Stephano J. Chang Iahn Cajigas Iahn Cajigas Ioan Opris James D. Guest James D. Guest James D. Guest Brian R. Noga Brian R. Noga Brian R. Noga Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation Frontiers in Systems Neuroscience mesencephalic locomotor region deep brain stimulation gait dysfunction cuneiform nucleus pedunculopontine nucleus |
| title | Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation |
| title_full | Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation |
| title_fullStr | Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation |
| title_full_unstemmed | Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation |
| title_short | Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation |
| title_sort | dissecting brainstem locomotor circuits converging evidence for cuneiform nucleus stimulation |
| topic | mesencephalic locomotor region deep brain stimulation gait dysfunction cuneiform nucleus pedunculopontine nucleus |
| url | https://www.frontiersin.org/article/10.3389/fnsys.2020.00064/full |
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