Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior

Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior

Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synaptic function, cognition, and social behavior. Howeve...

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Bibliographic Details
Main Authors: Kira V. Gromova, Mary Muhia, Nicola Rothammer, Christine E. Gee, Edda Thies, Irina Schaefer, Sabrina Kress, Manfred W. Kilimann, Olga Shevchuk, Thomas G. Oertner, Matthias Kneussel
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
autism spectrum disorder
synapse
neurobeachin
NMDA receptor
endosomal recycling
Rab GTPase
KIF21B
dynein
retromer
social behavior
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307125

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http://www.sciencedirect.com/science/article/pii/S2211124718307125

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