Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention

Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention

Background/Aims: One potential pathomechanism how low nephron number leads to hypertension in later life is altered salt handling. We therefore evaluated changes in electrolyte and water content in wildtype (wt) and GDNF+/- mice with a 30% reduction of nephron number. Methods: 32 GDNF+/- and 36 wt m...

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Bibliographic Details
Main Authors: Kerstin Benz, Julia Schlote, Christoph Daniel, Christoph Kopp, Anke Dahlmann, Agnes Schröder, Nada Cordasic, Bernd Klanke, Karl Hilgers, Jens Titze, Kerstin Amann
Format: Article
Language:English
Published: Karger Publishers 2018-01-01
Series:Kidney & Blood Pressure Research
Subjects:
High salt
Nephron number
Salt handling
Blood pressure
Chloride
Skin
Ashing
Online Access:https://www.karger.com/Article/FullText/486734

Internet

https://www.karger.com/Article/FullText/486734

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