Buffering by Transporters Can Spare Geometric Hindrance in Controlling Glutamate Escape

Buffering by Transporters Can Spare Geometric Hindrance in Controlling Glutamate Escape

The surface of astrocyte processes that often surround excitatory synapses is packed with high-affinity glutamate transporters, largely preventing extrasynaptic glutamate escape. The shape and prevalence of perisynaptic astroglia vary among brain regions, in some cases providing a complete isolation...

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Bibliographic Details
Main Authors: Leonid P. Savtchenko, Kaiyu Zheng, Dmitri A. Rusakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
excitatory synapse
glutamate
glutamate spillover
glutamate transporters
astrocyte
perisynaptic astroglial processes
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.707813/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.707813/full

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