Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2006-12-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600028&lng=en&tlng=en |
| _version_ | 1819327058878136320 |
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| author | Lorena Blau Renato Farina Menegon Man Chin Chung |
| author_facet | Lorena Blau Renato Farina Menegon Man Chin Chung |
| author_sort | Lorena Blau |
| collection | DOAJ |
| description | Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives. |
| first_indexed | 2024-12-24T13:04:49Z |
| format | Article |
| id | doaj.art-ca383c7cc9e24cb0b7c988f1412c372c |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-24T13:04:49Z |
| publishDate | 2006-12-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-ca383c7cc9e24cb0b7c988f1412c372c2022-12-21T16:54:03ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642006-12-012961307131710.1590/S0100-40422006000600028S0100-40422006000600028Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapiaLorena Blau0Renato Farina Menegon1Man Chin Chung2Universidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaStrategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600028&lng=en&tlng=enprodrugsenzymescancer |
| spellingShingle | Lorena Blau Renato Farina Menegon Man Chin Chung Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia Química Nova prodrugs enzymes cancer |
| title | Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia |
| title_full | Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia |
| title_fullStr | Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia |
| title_full_unstemmed | Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia |
| title_short | Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia |
| title_sort | pro farmaco ativado por enzima uma estrategia promissora na quimioterapia |
| topic | prodrugs enzymes cancer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600028&lng=en&tlng=en |
| work_keys_str_mv | AT lorenablau profarmacoativadoporenzimaumaestrategiapromissoranaquimioterapia AT renatofarinamenegon profarmacoativadoporenzimaumaestrategiapromissoranaquimioterapia AT manchinchung profarmacoativadoporenzimaumaestrategiapromissoranaquimioterapia |