Antigiardial activity of novel triazolyl quinolone-based chalcone derivatives: when oxygen makes the difference

Antigiardial activity of novel triazolyl quinolone-based chalcone derivatives: when oxygen makes the difference

Giardiasis is a common diarrheal disease worldwide caused by the protozoan parasite Giardia (G.) intestinalis. It is urgent to develop novel drugs to treat giardiasis, due to increasing clinical resistance to the gold standard drug metronidazole (MTZ). New potential antiparasitic compounds are usual...

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Bibliographic Details
Main Authors: Vijay eBahadur, Daniela eMastronicola, Amit Kumar Singh, Hemandra Kumar Tiwari, Leopoldo Paolo Pucillo, Paolo eSarti, Brajendra Kumar Singh, Alessandro eGiuffre
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Microbiology
Subjects:
drug screening
anaerobic protozoa
Synthetic compounds
Giardia intestinalis
Intestinal disease
microaerobiosis.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00256/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00256/full

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