A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties. We conducted a...

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Bibliographic Details
Main Authors: Nguyen TH Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le TP Thao, Nguyen TT Thuong, Ho DT Nghia, Nguyen HH Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen VV Chau, Jesmond Dalli, Guy E Thwaites
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
tuberculous meningitis
aspirin
infarction
clinical trial
Mycobacterium tuberculosis
Online Access:https://elifesciences.org/articles/33478

Internet

https://elifesciences.org/articles/33478

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