Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds

Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds

Cytotoxicity of de novo purine synthesis (DNPS) metabolites is critical to the pathogenesis of three known and one putative autosomal recessive disorder affecting DNPS. These rare disorders are caused by biallelic mutations in the DNPS genes phosphoribosylformylglycineamidine synthase (PFAS), phosph...

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Bibliographic Details
Main Authors: Olga Souckova, Vaclava Skopova, Veronika Baresova, David Sedlak, Anthony J. Bleyer, Stanislav Kmoch, Marie Zikanova
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Metabolites
Subjects:
purine synthesis
PFAS
PAICS
ADSL
ATIC
cytotoxicity
Online Access:https://www.mdpi.com/2218-1989/12/12/1210

Internet

https://www.mdpi.com/2218-1989/12/12/1210

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