Aneurysm-on-a-Chip: Setting Flow Parameters for Microfluidic Endothelial Cultures Based on Computational Fluid Dynamics Modeling of Intracranial Aneurysms

Aneurysm-on-a-Chip: Setting Flow Parameters for Microfluidic Endothelial Cultures Based on Computational Fluid Dynamics Modeling of Intracranial Aneurysms

Intracranial aneurysms are pouch-like extrusions from the vessels at the base of the brain which can rupture and cause a subarachnoid hemorrhage. The pathophysiological mechanism of aneurysm formation is thought to be a consequence of blood flow (hemodynamic) induced changes on the endothelium. In t...

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Bibliographic Details
Main Authors: Aisen Vivas, Julia Mikhal, Gabriela M. Ong, Anna Eigenbrodt, Andries D. van der Meer, Rene Aquarius, Bernard J. Geurts, Hieronymus D. Boogaarts
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Brain Sciences
Subjects:
intracranial aneurysm
aneurysm
organ on a chip
aneurysm on a chip
endothelial cells
computational fluid dynamics
Online Access:https://www.mdpi.com/2076-3425/12/5/603

Internet

https://www.mdpi.com/2076-3425/12/5/603

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