Improvements in Quality Control and Library Preparation for Targeted Sequencing Allowed Detection of Potentially Pathogenic Alterations in Circulating Cell-Free DNA Derived from Plasma of Brain Tumor Patients

Improvements in Quality Control and Library Preparation for Targeted Sequencing Allowed Detection of Potentially Pathogenic Alterations in Circulating Cell-Free DNA Derived from Plasma of Brain Tumor Patients

Malignant gliomas are the most frequent primary brain tumors in adults. They are genetically heterogenous and invariably recur due to incomplete surgery and therapy resistance. Circulating tumor DNA (ctDNA) is a component of circulating cell-free DNA (ccfDNA) and represents genetic material that ori...

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Bibliographic Details
Main Authors: Paulina Szadkowska, Adria-Jaume Roura, Bartosz Wojtas, Kamil Wojnicki, Sabina Licholai, Tomasz Waller, Tomasz Gubala, Kacper Zukowski, Michal Karpeta, Kinga Wilkus, Wojciech Kaspera, Sergiusz Nawrocki, Bozena Kaminska
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
liquid biopsy
glioma
circulating tumor DNA
ccfDNA
targeted NGS
Online Access:https://www.mdpi.com/2072-6694/14/16/3902

Internet

https://www.mdpi.com/2072-6694/14/16/3902

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