Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model

Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model

[INLINE:1] Activated G-protein-coupled receptor 39 (GPR39) has been shown to attenuate inflammation by interacting with sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). However, whether GPR39 attenuates neuropathic pain remains unclear. In this study, we es...

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Bibliographic Details
Main Authors: Longqing Zhang, Xi Tan, Fanhe Song, Danyang Li, Jiayi Wu, Shaojie Gao, Jia Sun, Daiqiang Liu, Yaqun Zhou, Wei Mei
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
g-protein-coupled receptor 39 (gpr39); neuroinflammation; neuropathic pain; nuclear respiratory factor 1 (nrf1); peroxisome proliferator-activated receptor-γ coactivator 1α (pgc-1α); sirtuin 1 (sirt1); spinal cord; mitochondrial transcription factor a (tfam)
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=3;spage=687;epage=696;aulast=Zhang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=3;spage=687;epage=696;aulast=Zhang

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