N-Acetylaspartate Drives Oligodendroglial Differentiation via Histone Deacetylase Activation

N-Acetylaspartate Drives Oligodendroglial Differentiation via Histone Deacetylase Activation

An unmet clinical goal in demyelinating pathologies is to restore the myelin sheath prior to neural degeneration. N-acetylaspartate (NAA) is an acetylated derivative form of aspartate, abundant in the healthy brain but severely reduced during traumatic brain injury and in patients with neurodegenera...

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Bibliographic Details
Main Authors: Alessandra Dominicis, Alice Del Giovane, Matteo Torreggiani, Antonella Damiana Recchia, Fabio Ciccarone, Maria Rosa Ciriolo, Antonella Ragnini-Wilson
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
remyelination
epigenetics
histone deacetylases (HDACs)
multiple sclerosis (MS)
N-acetylaspartate (NAA)
neurodegeneration
Online Access:https://www.mdpi.com/2073-4409/12/14/1861

Internet

https://www.mdpi.com/2073-4409/12/14/1861

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