Utility of Next-Generation Sequencing in the Reconstruction of Clonal Architecture in a Patient with an <i>EGFR</i> Mutated Advanced Non-Small Cell Lung Cancer: A Case Report

Utility of Next-Generation Sequencing in the Reconstruction of Clonal Architecture in a Patient with an <i>EGFR</i> Mutated Advanced Non-Small Cell Lung Cancer: A Case Report

EGFR tyrosine kinase inhibitors (EGFR-TKIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC) patients with activating <i>EGFR</i> mutations. However, targeted therapies impose a strong selective pressure against the coexisting tumor populations that lead to the eme...

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Bibliographic Details
Main Authors: Javier Simarro, Gema Pérez-Simó, Nuria Mancheño, Carlos Francisco Muñoz-Núñez, Enrique Cases, Óscar Juan, Sarai Palanca
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Diagnostics
Subjects:
non-small cell lung cancer
precision medicine
<i>EGFR</i> mutations
resistance mechanisms
molecular diagnostics
next-generation sequencing
Online Access:https://www.mdpi.com/2075-4418/12/5/1266

Internet

https://www.mdpi.com/2075-4418/12/5/1266

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