The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling
Abstract The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as a critical regulator of mammalian endocrine stress responses and as a potential pharmacological target for metabolic disorders, including type 2 diabetes (T2D). However, in β cells, which secrete the only glucose-lo...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-07-01
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Series: | Cell Death Discovery |
Online Access: | https://doi.org/10.1038/s41420-023-01506-x |