The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling

The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling

Abstract The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as a critical regulator of mammalian endocrine stress responses and as a potential pharmacological target for metabolic disorders, including type 2 diabetes (T2D). However, in β cells, which secrete the only glucose-lo...

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Main Authors: Na Liu, Rui Li, Jinglin Cao, Xinyao Song, Wenmiao Ma, Tengli Liu, Le Wang, Jiaqi Zou, Boya Zhang, Zewen Liu, Rui Liang, Rongxiu Zheng, Shusen Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01506-x

Internet

https://doi.org/10.1038/s41420-023-01506-x

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