Loss of 5′-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness

Loss of 5′-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness

The 5&#8217;-methylthioadenosine phosphorylase (MTAP) gene is located in the chromosomal region 9p21. <i>MTAP</i> deletion is a frequent event in a wide variety of human cancers; however, its biological role in tumorigenesis remains unclear. The purpose of this study was to character...

Full description

Bibliographic Details
Main Authors: Weder Pereira de Menezes, Viviane Aline Oliveira Silva, Izabela Natália Faria Gomes, Marcela Nunes Rosa, Maria Luisa Corcoll Spina, Adriana Cruvinel Carloni, Ana Laura Vieira Alves, Matias Melendez, Gisele Caravina Almeida, Luciane Sussuchi da Silva, Carlos Clara, Isabela Werneck da Cunha, Glaucia Noeli Maroso Hajj, Chris Jones, Lucas Tadeu Bidinotto, Rui Manuel Reis
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
glioma
glioblastoma
5’-methylthioadenosine phosphorylase (mtap)
immunohistochemistry
tumor biology
proliferation
migration
invasion
Online Access:https://www.mdpi.com/2073-4409/9/2/492

Internet

https://www.mdpi.com/2073-4409/9/2/492

Similar Items