Synthesis of 5,6-Dihydropyridin-2(1H)-ones, 1,5,6,8,8a-Hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-Hexahydroquinolin-2(1H)-ones by Intramolecular Wittig Reaction

Synthesis of 5,6-Dihydropyridin-2(1H)-ones, 1,5,6,8,8a-Hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-Hexahydroquinolin-2(1H)-ones by Intramolecular Wittig Reaction

A new, universal and diastereospecific method has been developed for the synthesis of 5,6-dihydropyridin-2(1H)-ones, 1,5,6,8,8a-hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8ahexahydroquinolin-2(1H)-ones (4) based on the intramolecular Wittig cyclization of the triphenyphosphonium salts 2 derived...

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Bibliographic Details
Main Authors: Nikolai V. Poendaev, Alexander S. Fisyuk
Format: Article
Language:English
Published: MDPI AG 2002-02-01
Series:Molecules
Subjects:
5
6-dihydropyridin-2(1H)-one
Wittig reaction
intramolecular cyclization
N-(3- oxoalkyl)chloroacetamide
Online Access:http://www.mdpi.com/1420-3049/7/2/124/

Internet

http://www.mdpi.com/1420-3049/7/2/124/

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