Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats. A simple and efficient high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) metho...

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Bibliographic Details
Main Authors: Huiyan Shi, Chenzhi Hou, Liqiang Gu, Zhe Wei, Hang Xing, Meiyu Zhang, Shixiao Wang, Longshan Zhao, Kaishun Bi, Xiaohui Chen
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Methotrexate
Piperazine ferulate
Pharmacokinetic parameters
HPLC-MS
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616300903

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http://www.sciencedirect.com/science/article/pii/S1818087616300903

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