Combinatorial Low Dose Arsenic Trioxide and Cisplatin Exacerbates Autophagy via AMPK/STAT3 Signaling on Targeting Head and Neck Cancer Initiating Cells

Combinatorial Low Dose Arsenic Trioxide and Cisplatin Exacerbates Autophagy via AMPK/STAT3 Signaling on Targeting Head and Neck Cancer Initiating Cells

Head and neck squamous cell carcinoma (HNSCC) is a highly lethal disease with high-level of epidemic both in the world and Taiwan. Previous studies support that head and neck cancer-initiating cells (HN-CICs), a subpopulation of cancer cells with enhanced stemness properties, contribute to therapy r...

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Bibliographic Details
Main Authors: Wei-Chun Hu, Wan-Huai Teo, Tung-Fu Huang, Te-Chang Lee, Jeng-Fan Lo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer-initiating cells
arsenic trioxide
combination index
autophagy
synergistic effects
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00463/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00463/full

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