Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation

Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation

Context Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease. Objective This study estimates the prot...

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Bibliographic Details
Main Authors: Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
chinese medicine
chemotherapeutic agent
oxidative stress
apoptosis
inflammation
Online Access:http://dx.doi.org/10.1080/13880209.2021.1990356

Internet

http://dx.doi.org/10.1080/13880209.2021.1990356

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