Maternal N-Acetylcysteine Therapy Prevents Hypertension in Spontaneously Hypertensive Rat Offspring: Implications of Hydrogen Sulfide-Generating Pathway and Gut Microbiota

Maternal N-Acetylcysteine Therapy Prevents Hypertension in Spontaneously Hypertensive Rat Offspring: Implications of Hydrogen Sulfide-Generating Pathway and Gut Microbiota

Hypertension can come from early life. N-acetylcysteine (NAC), a hydrogen sulfide (H<sub>2</sub>S) precursor as well as an antioxidant, has antihypertensive effect. We investigated whether maternal NAC therapy can protect spontaneously hypertensive rats (SHR) male offspring against hyper...

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Bibliographic Details
Main Authors: Chien-Ning Hsu, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, You-Lin Tain
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
developmental origins of health and disease (DOHaD)
gut microbiota
hydrogen sulfide
hypertension
N-acetylcysteine
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/9/9/856

Internet

https://www.mdpi.com/2076-3921/9/9/856

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