PEG-PCL Nanocapsules Containing Curcumin: Validation of HPLC Method for Analyzing Drug-loading Efficiency, Stability Testing and Cytotoxicity on NIH-3T3 Cell Line

PEG-PCL Nanocapsules Containing Curcumin: Validation of HPLC Method for Analyzing Drug-loading Efficiency, Stability Testing and Cytotoxicity on NIH-3T3 Cell Line

Abstract Curcumin (CUR) shows potential use for treating cancer. However, CUR has low solubility and reduced bioavailability, which limit its clinical effect. Therefore, the development of nanocarriers can overcome these problems and can ensure the desired pharmacological effect. In addition, it is...

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Bibliographic Details
Main Authors: Loanda Aparecida Cabral Rudnik, Amanda Martinez Lyra, Fernanda Malaquias Barboza, Traudi Klein, Carla Cristine Kanunfre, Paulo Vitor Farago, Sandra Maria Warumby Zanin, Jessica Mendes Nadal
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2020-10-01
Series:Brazilian Archives of Biology and Technology
Subjects:
curcumin
HPLC method
mouse embryonic fibroblast cell
MTT assay
nanotechnology
physicochemical stability testing
polymeric nanocapsules
polyphenol
SRB assay
zeta potential
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100322&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100322&tlng=en

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