Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

Summary: Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35 (GPR35) are associated with increased risk of inflammatory bowel disease. However, the mechanisms by which GPR35 modulates intestinal immune homeostasis remain undefined. Here, integrating zebrafish and mouse...

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Bibliographic Details
Main Authors: Berna Kaya, Cristian Doñas, Philipp Wuggenig, Oscar E. Diaz, Rodrigo A. Morales, Hassan Melhem, Pedro P. Hernández, Tanay Kaymak, Srustidhar Das, Petr Hruz, Yannick Franc, Florian Geier, C. Korcan Ayata, Eduardo J. Villablanca, Jan Hendrik Niess
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
GPR35
lysophosphatidic acid
macrophages
colitis
zebrafish
intestine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309645

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http://www.sciencedirect.com/science/article/pii/S2211124720309645

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