Structure-Guided Development of Bivalent Aptamers Blocking SARS-CoV-2 Infection

Structure-Guided Development of Bivalent Aptamers Blocking SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused devastation to human society through its high virulence, infectivity, and genomic mutations, which reduced the efficacy of vaccines. Here, we report the development of aptamers that effectively interfere with SARS-CoV-2 infectio...

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Bibliographic Details
Main Authors: Md Shafiqur Rahman, Min Jung Han, Sang Won Kim, Seong Mu Kang, Bo Ri Kim, Heesun Kim, Chang Jun Lee, Jung Eun Noh, Hanseong Kim, Jie-Oh Lee, Sung Key Jang
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
SARS-CoV-2
aptamer–RBD complex
cryo-EM structure
Nap-dU
neutralization
viro-SELEX
Online Access:https://www.mdpi.com/1420-3049/28/12/4645

Internet

https://www.mdpi.com/1420-3049/28/12/4645

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