(2R,4aS,6aS,12bR,14aS,14bR)10-Hydroxy-<i>N</i>-(4-((6-methoxyquinolin-8-yl)amino)pentyl)-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxamide

(2R,4aS,6aS,12bR,14aS,14bR)10-Hydroxy-<i>N</i>-(4-((6-methoxyquinolin-8-yl)amino)pentyl)-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxamide

We herein report the synthesis of a derivative of the natural compound celastrol linked to the antimalarial drug primaquine through an amide obtained by the activation of the carboxylic acid with HOBt/EDC. The chemical structure of the new molecule was fully characterized by proton nuclear magnetic...

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Bibliographic Details
Main Authors: Yuhan Xie, Houin Kuan, Qin Wei, Alessandra Gianoncelli, Giovanni Ribaudo, Paolo Coghi
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molbank
Subjects:
triterpenoids
coupling
drug discovery
molecular docking
SERCA
Online Access:https://www.mdpi.com/1422-8599/2023/3/M1716

Internet

https://www.mdpi.com/1422-8599/2023/3/M1716

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