MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells

MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells

Chondrosarcomas and osteosarcomas are malignant bone tumors with a poor prognosis when unresectable or metastasized. Moreover, radiotherapy and chemotherapy could be ineffective. MiRNAs represent an alternative therapeutic approach. Based on high-throughput functional screening, we identified four m...

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Bibliographic Details
Main Authors: Clément Veys, Flavie Boulouard, Abderrahim Benmoussa, Manon Jammes, Emilie Brotin, Françoise Rédini, Laurent Poulain, Nicolas Gruchy, Christophe Denoyelle, Florence Legendre, Philippe Galera
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
osteosarcoma
chondrosarcoma
miR-4270
miR-342-5p
apoptosis
Bcl-XL
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1220459/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1220459/full

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