Minocycline relieves neuropathic pain in rats with spinal cord injury via activation of autophagy and suppression of PI3K/Akt/mTOR pathway

Objective: In this study, we studied whether minocycline hydrochloride improved neuropathic pain induced by spinal cord injury (SCI) in rats through PI3K/Akt pathway. Methods: The SCI was induced by compressed at level of T9-T11 of spinal cord in Sprague Dawley male rats. Animals were given differen...

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Bibliographic Details
Main Authors: Leyan Qiao, Qian Tang, Zhongzhe An, Jun Qi
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000361