Clinical efficacy and neurobiological correlates of electroconvulsive therapy in patients with clozapine-resistant/intolerant schizophrenia: study protocol of multi-site parallel arm double-blind randomized sham-controlled study [version 2; peer review: 1 approved, 2 approved with reservations]

Clinical efficacy and neurobiological correlates of electroconvulsive therapy in patients with clozapine-resistant/intolerant schizophrenia: study protocol of multi-site parallel arm double-blind randomized sham-controlled study [version 2; peer review: 1 approved, 2 approved with reservations]

Background: A substantial proportion of patients with treatment resistant schizophrenia do not respond well or partially to clozapine, with a subset that does not tolerate an adequate trial of clozapine. Electroconvulsive therapy (ECT) is regarded as one of the augmenting options, but there is a lac...

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Main Authors: Channaveerachari Naveen Kumar, Kandavel Thennarasu, Basudeb Das, Nishant Goyal, Kesavan Muralidharan, Urvakhsh Meherwan Mehta, Preeti Sinha, Ganesan Venkatasubramanian, Jagadisha Thirthalli, Shyam Sundar Arumugham, Umesh Shreekantiah, Samir K. Praharaj, Chandramouli Roy, Vanteemar S. Sreeraj, Abhiram Narasimhan Purohith, Sonia Shenoy, Kiran Basawaraj Bagali, Uppinkudru Chithra, Gopala Krishna Kadarapura Nanjundaiah, Sudhir Venkataramaiah
Format: Article
Language:English
Published: Wellcome 2022-10-01
Series:Wellcome Open Research
Subjects:
electroconvulsive therapy
clozapine
treatment-resistance
schizophrenia
eng
Online Access:https://wellcomeopenresearch.org/articles/7-212/v2

Internet

https://wellcomeopenresearch.org/articles/7-212/v2

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