CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway
Abstract CD5 molecule like (CD5L), a member of the scavenger receptor cysteine-rich domain superfamily, plays a critical role in immune homeostasis and inflammatory disease. Acetaminophen (APAP) is a safe and effective antipyretic analgesic. However, overdose may cause liver damage or even liver fai...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-11-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-021-00742-3 |
| _version_ | 1819006973667966976 |
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| author | Mengjing Li Tao Ling Fengmeng Teng Chao Hu Zhongping Su Chen Zhang Xiang Li Ting Zhao Xianmin Mu Yingchang Li Jinshun Pan Qiang You |
| author_facet | Mengjing Li Tao Ling Fengmeng Teng Chao Hu Zhongping Su Chen Zhang Xiang Li Ting Zhao Xianmin Mu Yingchang Li Jinshun Pan Qiang You |
| author_sort | Mengjing Li |
| collection | DOAJ |
| description | Abstract CD5 molecule like (CD5L), a member of the scavenger receptor cysteine-rich domain superfamily, plays a critical role in immune homeostasis and inflammatory disease. Acetaminophen (APAP) is a safe and effective antipyretic analgesic. However, overdose may cause liver damage or even liver failure. APAP hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response, in which the role of CD5L remains to be investigated. In this study, we found that the expression of CD5L was increased in the livers of mice after APAP overdose. Furthermore, CD5L deficiency reduced the increase of alanine transaminase (ALT) level, histopathologic lesion area, c-Jun N-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK) phosphorylation level, Transferase-Mediated dUTP Nick End-Labeling positive (TUNEL+) cells proportion, vascular endothelial cell permeability and release of inflammatory cytokines induced by excess APAP. Therefore, our findings reveal that CD5L may be a potential therapeutic target for prevention and treatment of APAP-induced liver injury. |
| first_indexed | 2024-12-21T00:17:12Z |
| format | Article |
| id | doaj.art-ca6ed55cf1f44af9be5ac7940ab9efec |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-12-21T00:17:12Z |
| publishDate | 2021-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-ca6ed55cf1f44af9be5ac7940ab9efec2022-12-21T19:22:11ZengNature Publishing GroupCell Death Discovery2058-77162021-11-017111110.1038/s41420-021-00742-3CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathwayMengjing Li0Tao Ling1Fengmeng Teng2Chao Hu3Zhongping Su4Chen Zhang5Xiang Li6Ting Zhao7Xianmin Mu8Yingchang Li9Jinshun Pan10Qiang You11Department of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityAffilated Hospital of Nanjing University of Chinese MedicineDepartment of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityAffilated Hospital of Nanjing University of Chinese MedicineAffiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityAffiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Biotherapy, Department of Geriatrics, Second Affiliated Hospital of Nanjing Medical UniversityAbstract CD5 molecule like (CD5L), a member of the scavenger receptor cysteine-rich domain superfamily, plays a critical role in immune homeostasis and inflammatory disease. Acetaminophen (APAP) is a safe and effective antipyretic analgesic. However, overdose may cause liver damage or even liver failure. APAP hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response, in which the role of CD5L remains to be investigated. In this study, we found that the expression of CD5L was increased in the livers of mice after APAP overdose. Furthermore, CD5L deficiency reduced the increase of alanine transaminase (ALT) level, histopathologic lesion area, c-Jun N-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK) phosphorylation level, Transferase-Mediated dUTP Nick End-Labeling positive (TUNEL+) cells proportion, vascular endothelial cell permeability and release of inflammatory cytokines induced by excess APAP. Therefore, our findings reveal that CD5L may be a potential therapeutic target for prevention and treatment of APAP-induced liver injury.https://doi.org/10.1038/s41420-021-00742-3 |
| spellingShingle | Mengjing Li Tao Ling Fengmeng Teng Chao Hu Zhongping Su Chen Zhang Xiang Li Ting Zhao Xianmin Mu Yingchang Li Jinshun Pan Qiang You CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway Cell Death Discovery |
| title | CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway |
| title_full | CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway |
| title_fullStr | CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway |
| title_full_unstemmed | CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway |
| title_short | CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway |
| title_sort | cd5l deficiency attenuate acetaminophen induced liver damage in mice via regulation of jnk and erk signaling pathway |
| url | https://doi.org/10.1038/s41420-021-00742-3 |
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