Cochaperones convey the energy of ATP hydrolysis for directional action of Hsp90

Abstract The molecular chaperone and heat shock protein Hsp90 is part of many protein complexes in eukaryotic cells. Together with its cochaperones, Hsp90 is responsible for the maturation of hundreds of clients. Although having been investigated for decades, it still is largely unknown which compon...

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Bibliographic Details
Main Authors: Leonie Vollmar, Julia Schimpf, Bianca Hermann, Thorsten Hugel
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44847-6