Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms

Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms

Abstract Pleomorphic dermal sarcomas are infrequent neoplastic skin tumors, manifesting in regions of the skin exposed to ultraviolet radiation. Diagnosing the entity can be challenging and therapeutic options are limited. We analyzed 20 samples of normal healthy skin tissue (SNT), 27 malignant mela...

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Bibliographic Details
Main Authors: Sebastian Klein, Yuri Tolkach, Hans Christian Reinhardt, Reinhard Buettner, Alexander Quaas, Doris Helbig
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Pleomorphic dermal sarcoma
PDS
Protein profiling
Fibroblastic differentiation
Immune escape mechanisms
Cutaneous sarcoma
Online Access:https://doi.org/10.1038/s41598-024-62927-x

Internet

https://doi.org/10.1038/s41598-024-62927-x

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