Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

The long-lasting loss of sleep is a generally acknowledged risk factor for the occurrence of major depressive disorder (MDD), whereas sleep abnormalities being a key clinic symptom of the MDD. In our previous work, we demonstrated that the sleep deprivation (SD) stimulates activation of nucleotide-b...

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Bibliographic Details
Main Authors: Xiaowei Li, Shanshan Liang, Zexiong Li, Shuai Li, Maosheng Xia, Alexei Verkhratsky, Baoman Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Psychiatry
Subjects:
sleep deprivation
5-HT2B receptors
astrocytes
fluoxetine
leptin
NLRP3 inflammasomes
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00734/full

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https://www.frontiersin.org/article/10.3389/fpsyt.2018.00734/full

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