Bacterial Expression of TMTP1-Fused L-Asparaginase for Targeting Leukemia and Metastatic Tumor Cells

Bacterial Expression of TMTP1-Fused L-Asparaginase for Targeting Leukemia and Metastatic Tumor Cells

L-asparaginase is recognized as a first-line anticancer drug for acute lymphoblastic leukemia (ALL); however, low-substrate specificity and exhibiting glutaminase activity cause various off-target toxicities on normal cells. In the following study, we functionalized wild-type asparaginase with the...

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Bibliographic Details
Main Authors: Mohammad Hassan Kheirandish, Mohammad Tollabi, Fatemeh Davami, Behnaz Rahmani, Negin Sadat Hashemi Aval, Javad Behroozi, Hossein Zarei Jaliani
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2023-07-01
Series:Acta Medica Iranica
Subjects:
L-asparaginase
TMTP1 targeting peptide
Acute lymphoblastic leukemia
Restriction endonuclease-free cloning
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/10492

Internet

https://acta.tums.ac.ir/index.php/acta/article/view/10492

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