Comparative identification of the metabolites of dehydrocorydaline from rat plasma, bile, urine and feces by both the targeted and untargeted liquid chromatography/mass spectrometry strategies

Comparative identification of the metabolites of dehydrocorydaline from rat plasma, bile, urine and feces by both the targeted and untargeted liquid chromatography/mass spectrometry strategies

Severe interference from the endogenous substances is often encountered in characterizing the drug metabolites by liquid chromatography/mass spectrometry using data-dependent acquisition (DDA). To add a precursor ions list (PIL) by DDA or apply data-independent acquisition (DIA) coupled with post-ac...

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Bibliographic Details
Main Authors: Yueguang Mi, Xiangyang Wang, Meiting Jiang, Meiyu Liu, Xiaoyan Xu, Ying Hu, Hongda Wang, Feifei Yang, Jing Wang, Jie Liu, Qi Jing, Boxue Chen, Xue Li, Wenzhi Yang
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Arabian Journal of Chemistry
Subjects:
Dehydrocorynine
Precursor ions list
Data-dependent acquisition
Data-independent acquisition
Mass defect filtering
Metabolite characterization
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222002842

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http://www.sciencedirect.com/science/article/pii/S1878535222002842

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