New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.

New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.

The hepatitis C virus (HCV) genome encodes a long polyprotein, which is processed by host cell and viral proteases to the individual structural and non-structural (NS) proteins. HCV NS3/4A serine proteinase (NS3/4A) is a non-covalent heterodimer of the N-terminal, ∼180-residue portion of the 631-res...

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Bibliographic Details
Main Authors: Sergey A Shiryaev, Elliot R Thomsen, Piotr Cieplak, Eugene Chudin, Anton V Cheltsov, Mark S Chee, Igor A Kozlov, Alex Y Strongin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338790?pdf=render

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http://europepmc.org/articles/PMC3338790?pdf=render

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