Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

Abstract The development of multidrug resistance (MDR) during cancer chemotherapy is a major challenge in current cancer treatment strategies. Numerous molecular mechanisms, including increased drug efflux, evasion of drug-induced apoptosis, and activation of DNA repair mechanisms, can drive chemoth...

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Bibliographic Details
Main Authors: Xiangyang Zhang, Min Wang, Junyi Feng, Bin Qin, Chenglin Zhang, Chengshen Zhu, Wentao Liu, Yaohe Wang, Wei Liu, Lei Huang, Shuangshuang Lu, Zhimin Wang
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
Tumor targeting
Chemotherapy
siRNA
Multidrug resistance
Esophageal cancer
Online Access:https://doi.org/10.1186/s12951-022-01377-x

Internet

https://doi.org/10.1186/s12951-022-01377-x

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