Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with <i>Cinchona</i> Alkaloids: Induction of Fetal Hemoglobin Production

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with <i>Cinchona</i> Alkaloids: Induction of Fetal Hemoglobin Production

β-thalassemias are among the most common inherited hemoglobinopathies worldwide and are the result of autosomal mutations in the gene encoding β-globin, causing an absence or low-level production of adult hemoglobin (HbA). Induction of fetal hemoglobin (HbF) is considered to be of key importance for...

Full description

Bibliographic Details
Main Authors: Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Ilaria Lampronti, Monica Borgatti, Chiara Scapoli, Roberto Gambari, Alessia Finotti
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
β-thalassemia
fetal hemoglobin
γ-globin
HbF induction
K562 cells
<i>Cinchona</i> alkaloids
Online Access:https://www.mdpi.com/1422-0067/22/24/13433

Internet

https://www.mdpi.com/1422-0067/22/24/13433

Similar Items