SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis

SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis

Abstract Objective Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. Over-activation of fibroblast-like synoviocytes is responsible for the hyperplasia of synovium and destruction of cartilage and bone and pyroptosis of FLS plays a key role in those pathological processes durin...

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Bibliographic Details
Main Authors: Xingxing Mao, Weijie Wu, Yunyi Nan, Weiwei Sun, Youhua Wang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Arthritis Research & Therapy
Subjects:
SMAD2
Pyroptosis
Rheumatoid arthritis
TGF-β
Fibroblast-like synoviocytes
Online Access:https://doi.org/10.1186/s13075-023-03136-1

Internet

https://doi.org/10.1186/s13075-023-03136-1

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