PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis

PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis

At homeostasis, a substantial proportion of Foxp3+ T regulatory cells (Tregs) have an activated phenotype associated with enhanced TCR signals and these effector Treg cells (eTregs) co-express elevated levels of PD-1 and CTLA-4. Short term in vivo blockade of the PD-1 or CTLA-4 pathways results in i...

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Bibliographic Details
Main Authors: Joseph A. Pereira, Zachary Lanzar, Joseph T. Clark, Andrew P. Hart, Bonnie B. Douglas, Lindsey Shallberg, Keenan O’Dea, David A. Christian, Christopher A. Hunter
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
treg - regulatory T cell
checkpoint blockade immunotherapy
PD-1 - PD-L1 axis
CTLA-4 (cytotoxic T lymphocyte-associated antigen 4)
homeostatic regulation
immune suppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.997376/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.997376/full

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