Resurrection of a Viral Internal Ribosome Entry Site from a 700 Year Old Ancient Northwest Territories Cripavirus

Resurrection of a Viral Internal Ribosome Entry Site from a 700 Year Old Ancient Northwest Territories Cripavirus

The dicistrovirus intergenic region internal ribosome entry site (IGR IRES) uses an unprecedented, streamlined mechanism whereby the IRES adopts a triple-pseudoknot (PK) structure to directly bind to the conserved core of the ribosome and drive translation from a non-AUG codon. The origin of this IR...

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Bibliographic Details
Main Authors: Xinying Wang, Marli Vlok, Stephane Flibotte, Eric Jan
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
dicistrovirus
RNA
internal ribosome entry site
translation
ribosome
infectious clone
Online Access:https://www.mdpi.com/1999-4915/13/3/493

Internet

https://www.mdpi.com/1999-4915/13/3/493

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