The Yin and Yang of Pneumolysin During Pneumococcal Infection

The Yin and Yang of Pneumolysin During Pneumococcal Infection

Pneumolysin (PLY) is a pore-forming toxin produced by the human pathobiont Streptococcus pneumoniae, the major cause of pneumonia worldwide. PLY, a key pneumococcal virulence factor, can form transmembrane pores in host cells, disrupting plasma membrane integrity and deregulating cellular homeostasi...

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Bibliographic Details
Main Authors: Joana M. Pereira, Shuying Xu, John M. Leong, Sandra Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pneumoniae
pore-forming toxin
cholesterol-dependent cytolysin
plasma membrane
pneumonia
pro- and anti-inflammatory immune responses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.878244/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.878244/full

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