A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing

A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing

Achieving spatial control of gene expression is important. Here the authors report an optimised photoactivatable Cre recombinase system, doxycycline- and light-inducible Cre recombinase (DiLiCre), and generate a DiLiCre mouse line which they use for mutagenesis in vivo and positional cell-tracing.

Bibliographic Details
Main Authors: Miguel Vizoso, Colin E. J. Pritchard, Lorenzo Bombardelli, Bram van den Broek, Paul Krimpenfort, Roderick L. Beijersbergen, Kees Jalink, Jacco van Rheenen
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33863-z

Internet

https://doi.org/10.1038/s41467-022-33863-z

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