Altered muscle niche contributes to myogenic deficit in the D2-mdx model of severe DMD

Altered muscle niche contributes to myogenic deficit in the D2-mdx model of severe DMD

Abstract Lack of dystrophin expression is the underlying genetic basis for Duchenne muscular dystrophy (DMD). However, disease severity varies between patients, based on specific genetic modifiers. D2-mdx is a model for severe DMD that exhibits exacerbated muscle degeneration and failure to regenera...

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Bibliographic Details
Main Authors: Davi A. G. Mázala, Ravi Hindupur, Young Jae Moon, Fatima Shaikh, Iteoluwakishi H. Gamu, Dhruv Alladi, Georgiana Panci, Michèle Weiss-Gayet, Bénédicte Chazaud, Terence A. Partridge, James S. Novak, Jyoti K. Jaiswal
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01503-0

Internet

https://doi.org/10.1038/s41420-023-01503-0

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