Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma

Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma

Obesity and associated changes to the gut microbiome worsen airway inflammation and hyperresponsiveness in asthma. Obesogenic host-microbial metabolomes have altered production of metabolites that may influence lung function and inflammatory responses in asthma. To understand the interplay of the gu...

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Bibliographic Details
Main Authors: Victoria A. Heinrich, Crystal Uvalle, Michelle L. Manni, Kelvin Li, Steven J. Mullett, Sri Ramya Donepudi, Jason Clader, Adam Fitch, Madeline Ellgass, Veronika Cechova, Shulin Qin, Fernando Holguin, Bruce A. Freeman, Barbara A. Methé, Alison Morris, Stacy L. Gelhaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Microbiomes
Subjects:
asthma
microbiome
obesity
metabolomics
multi-omics analyses
elastance
Online Access:https://www.frontiersin.org/articles/10.3389/frmbi.2023.1153691/full

Internet

https://www.frontiersin.org/articles/10.3389/frmbi.2023.1153691/full

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