Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Abstract Background Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2 (LMP2) in the pathophysiology of ischemia stroke. However, the...

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Bibliographic Details
Main Authors: Xing-Yong Chen, Shao-Fen Wan, Nan-Nan Yao, Ze-Jing Lin, Yan-Guang Mao, Xiao-Hua Yu, Yin-Zhou Wang
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Military Medical Research
Subjects:
Immunoproteasome
Blood–brain barrier
Wnt/β-catenin pathway
Oxygen–glucose deprivation/reperfusion
Cerebral ischemia
Online Access:https://doi.org/10.1186/s40779-021-00356-x

Internet

https://doi.org/10.1186/s40779-021-00356-x

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