The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

The present study aimed to optimize a liposomal formulation co-encapsulating simvastatin (SIM) and doxorubicin (DOX) that has future perspectives in anticancer therapy. The optimization process was performed by implementing the Quality by Design concept and by considering the results of a previous s...

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Bibliographic Details
Main Authors: Cristina-Ioana Barbalata, Alina Silvia Porfire, Tibor Casian, Dana Muntean, Iulia Rus, Mihaela Tertis, Cecilia Cristea, Anca Pop, Julien Cherfan, Felicia Loghin, Ioan Tomuta
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
QbD
liposomes
chronoamperometry
synergism
Online Access:https://www.mdpi.com/1424-8247/15/10/1211

Internet

https://www.mdpi.com/1424-8247/15/10/1211

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