A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition

A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition

A vesicular stomatitis virus (VSV)-based assay enables high-throughput screening for small molecular protease inhibitors that can block viral proteases, like the Mpro/3CLpro/Nsp5 in SARS-CoV-2.

Bibliographic Details
Main Authors: Emmanuel Heilmann, Francesco Costacurta, Stephan Geley, Seyad Arad Mogadashi, Andre Volland, Bernhard Rupp, Reuben Stewart Harris, Dorothee von Laer
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03277-0

Internet

https://doi.org/10.1038/s42003-022-03277-0

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