Effect of GRK4 on renal gastrin receptor regulation in hypertension

Objective To investigate whether GRK4 regulates the phosphorylation and function of renal CCKBR. Methods GRK4 A142V transgenic mice were used as an animal model of enhanced GRK4 activity, and siRNA was used to silence the GRK4 gene to investigate the regulatory effect of GRK4 on CCKBR phosphorylatio...

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Bibliographic Details
Main Authors: Xuewei Xia, Yongchun Zeng, Zhuxin Li, Hao Luo, Wei Wang, Yanji He, Bingjun Lu, Jingwen Guo, Ken Chen, Xiang Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Clinical and Experimental Hypertension
Subjects:
Online Access:http://dx.doi.org/10.1080/10641963.2023.2245580